The haemoglobin enzyme

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Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia.

The switchover from foetal to adult haemoglobin synthesis, which is normally complete by the end of the first year of life, is accompanied by marked changes in the red cell enzyme pattern. In particular, the level of carbonic anhydrase, which is very low in cord blood, rapidly increases during the first year of life to become the most abundant of the red cell nonhaemoglobin proteins. There have...

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Comparison of erythrocyte antioxidative enzyme activities between two types of haemoglobin H disease.

The activities of erythrocyte antioxidative enzymes were measured in two groups of patients with different genotypes of haemoglobin (Hb) H disease: 21 with alpha-thalassaemia 1 or alpha-thalassaemia 2 (alpha-thalassaemia 1/2) and 21 with alpha-thalassaemia 1/Hb Constant Spring (HbCS). They were compared with 21 normal subjects. Both genotypes of Hb H disease had increased activities of erythroc...

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The haemoglobin types of mice.

The haemoglobin types of 27 inbred strains of mice have been determined. Besides the common types, Hbb-s and Hbb-p, 2 strains were found with Hbb-p. Affinity between strains with the Hbb-p type and asiatic mice seems likely. The influence of storage on the polymerisation of Hbb-d and Hbb-p, the possibility of distinguishing between homo- and heterozygote Hbb types, and the possible existence o...

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The Kinetics of Enzyme Mixtures

Even purified enzyme preparations are often heterogeneous. For example, preparations of aspartate aminotransferase or cytochrome oxidase can consist of several different forms of the enzyme.  For this reason we consider how different the kinetics of the reactions catalysed by a mixture of forms of an enzyme must be to provide some indication of the characteristics of the species present.  Based...

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The erroneous haemoglobin-hyperlipidaemia relationship.

Hyperlipidaemia, whether primary or secondary to parenteral feeding with intravenous lipid emulsions, causes the haemoglobin level to be erroneously high when measured spectrophotometrically. Contrary to a previous report, evidence is presented which suggests a relationship between the amount of the false rise in the haemoglobin level and the type and degree of hyperlipidaemia.

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ژورنال

عنوان ژورنال: Nature

سال: 1999

ISSN: 0028-0836,1476-4687

DOI: 10.1038/46707